Statistica 10 Rus Torrent

Pre-eclampsia (PE) is a complication of pregnancy that affects 5‑8% of women after 20 weeks of gestation. It is usually diagnosed based on the de novo onset of hypertension and proteinuria. Preexisting hypertension in women developing PE, also known as superimposed PE on chronic hypertension (SPE), leads to elevated risk of maternal and fetal mortality. PE is associated with an altered microRNA (miRNA) expression pattern in the placenta, suggesting that miRNA deregulation is involved in the pathogenesis of PE. Whether and how the miRNA expression pattern is changed in the SPE placenta remains unclear. The present study analyzed the placental miRNA expression profile in pregnancies complicated by SPE.

MiRNA expression profiles in SPE and normal placentas were investigated using an Ion Torrent sequencing system. Sequencing data were processed using a comprehensive analysis pipeline for deep miRNA sequencing (CAP‑miRSeq).

Impressive Torrents Picker: statistica 10 Top 100 Top Today Top Search Getting started FAQ. ADD to search engine list. Statistica Neural Networks) [2006, PDF, RUS].

A total of 22 miRNAs were identified to be deregulated in placentas from patients with SPE. They included 16 miRNAs previously known to be associated with PE and 6 novel miRNAs. Among the 6 novel miRNAs, 4 were upregulated (miR‑518a, miR‑527, miR‑518e and miR‑4532) and 2 downregulated (miR‑98 and miR‑135b) in SPE placentas compared with controls.

Vizitka klassa na konkurs samij klassnij klass prezentaciya. Stability is very important. They will decide if we can stay or not, and then they’ll slide the paper under the door.” She pointed to the end of the dim hallway as if this paper might appear at any moment, sliding in silently like the checkout bill in a hotel room.

The present results suggest that SPE is associated with specific alterations in the placental miRNA expression pattern, which differ from alterations detected in PE placentas, and therefore, provide novel targets for further investigation of the molecular mechanisms underlying SPE pathogenesis. Introduction Pre-eclampsia (PE) is a complication of pregnancy characterized by the onset of hypertension and proteinuria after 20 weeks of gestation. It affects 5–8% of pregnant women and is one of the predominant causes of maternal and neonatal mortality and morbidity worldwide (,). Women with chronic hypertension are 3–5 times more likely to develop PE than those with normal blood pressure (). Superimposed PE on chronic hypertension (SPE) is associated with poor pregnancy out comes (,).

Despite the fact that the origin and pathogenesis of both PE and SPE have been extensively investigated (,,–), they remain unclear to date. Recent studies have reported the implication of microRNAs (miRNAs) in the development of PE (,). MiRNAs are a class of 21–25-nucleotide noncoding single-stranded small RNAs. MiRNAs negatively regulate gene expression by binding to the 3′-untranslated region of the target mRNAs and thus may possess important control functions in diverse biological processes (,,).